ABSTRACT
Background: Fatty liver disease [FLD] is a common disorder with an increasing prevalence. It is considered to be an important syndrome associated with several cardiovascular risk factors and to be a component of metabolic syndrome. Several studies found significant association of fatty liver and coronary artery disease [CAD]
Aim of the Work: was to evaluate the presence and the severity of coronary artery disease among FLD population and to evaluate the association of FLD and CAD using Multi-Slice Computed Tomography [MSCT] and the possibility of considering FLD as a predictor for CAD
Patients and Methods: The study was conducted in Radiological Department of Ain-Shams Hospital and other private centers. It focused on evaluating 30 patients, who were referred to perform CT coronary angiography. These patients were examined in the period between 1[st] of Oct. 2017 and 1[st] of Apr. 2018. The target sample was patients with fatty liver who underwent CT coronary angiography for recent chest pain. Fatty liver was diagnosed using non-contrast CT when calculated attenuation value of the liver is less than spleen by 10 UH. The coronary arteries were assessed using CT angiography, significant CAD was defined as a stenosis of more than 50% in at least one major coronary artery
Results: fatty liver developed coronary atherosclerosis were 17 [56.7%] and this was statistically significant P= 0.017. Patients with fatty liver developed significant CAD were 9 [30.0%] and this was statistically insignificant P=0.266
Conclusion: Fatty liver disease may be considered as a predictor for coronary atherosclerosis and based on this, more individuals from the general population with subclinical CAD could be detected at earlier stages when fatty liver is identified. Presence of fatty liver may help in cardiovascular risk stratification and assessment
Recommendations: It will be worthwhile to study whether improving FLD will ultimately prevent the development of CAD